Who: Donald M. Berwick, M.D.

Current position: Administrator, Centers for Medicare and Medicaid Services, U.S. Department of Health and Human Services

Location: Washington, D.C.

Fast facts: A longtime champion of patient safety, Berwick co-founded the Institute of Healthcare Improvement in 1989 and led it until he became CMS administrator by virtue of a controversial "recess appointment" in July 2010, preventing the Senate from questioning him about his views. At IHI, Berwick created and championed the 100,000 Lives Campaign, an effort to prevent that many deaths in an 18-month period by getting thousands of U.S. hospitals to follow simple, preventive safety measures voluntarily. The program later turned its focus to nonlethal adverse events and became the 5 Million Lives Campaign. Berwick is a pediatrician who also holds a master's degree in public policy.

What makes him disruptive: In kicking off the 100,000 Lives Campaign in December 2004, Berwick made the following audacious challenge to American hospitals: "I think we should save 100,000 lives. I think we should do that by June 14, 2006. 9 a.m." At that appointed hour 18 months later, he announced that the campaign had prevented 122,300 unnecessary deaths. Berwick was careful not to make IT a prerequisite for participating in either campaign, but he's come to see the benefits of EMRs and clinical decision support. Now, as head of CMS, he effectively leads the "meaningful use" incentive program. Though the Stage 1 rules were mostly done by the time he took the reins, you can be sure Berwick will be pushing for true quality improvement in subsequent stages of meaningful use.